What is the recommended management for NSAID-induced peptic ulcer disease?

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Multiple Choice

What is the recommended management for NSAID-induced peptic ulcer disease?

NSAID-induced peptic ulcer disease is managed by removing the source of injury, protecting the stomach, addressing infection if present, and choosing safer pain options. Discontinue NSAIDs if possible to stop ongoing mucosal damage; if they must be used, use the lowest effective dose and pair with a proton pump inhibitor to promote healing and reduce recurrence. Test for H. pylori and treat if positive, because eradication lowers ulcer recurrence and improves healing. Finally, reassess analgesia by considering alternatives such as acetaminophen or non-NSAID options, and, if NSAID use is unavoidable, consider a COX-2 inhibitor with GI protection. The other approaches miss one or more of these essential steps, leaving ongoing risk or recurrence.

NSAID-induced peptic ulcer disease is managed by removing the source of injury, protecting the stomach, addressing infection if present, and choosing safer pain options. Discontinue NSAIDs if possible to stop ongoing mucosal damage; if they must be used, use the lowest effective dose and pair with a proton pump inhibitor to promote healing and reduce recurrence. Test for H. pylori and treat if positive, because eradication lowers ulcer recurrence and improves healing. Finally, reassess analgesia by considering alternatives such as acetaminophen or non-NSAID options, and, if NSAID use is unavoidable, consider a COX-2 inhibitor with GI protection. The other approaches miss one or more of these essential steps, leaving ongoing risk or recurrence.

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